Abstract
Exogenous oestrogens, progesterone and progestogens are prescribed for a variety of conditions in spite of lack of proof of efficacy. Supraphysiological levels of oestrogen and progesterone have occurred in some individuals due to demands for increased doses. Brain function, amine metabolism and nutritional status can be altered by exposure to exogenous hormones. Direct and indirect mechanisms of psychoactivity may induce dependency. A doctor's severe 'menopausal type' withdrawal symptoms after exposure to oral conjugated oestrogens (Premarin 625 mu g/day) are reported.