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Abstract
Objectives
The aim of this study was to explore the association between unintended pregnancy and related factors among congenital heart defects (CHDs) in infants.
Methods
A total of 1197 cases with isolated CHDs and 1125 controls without any abnormalities were analysed in this multicentre study at seven hospitals in China. According to the pregnancy intention, cases were divided into two groups: planned and unintended pregnancies. The adjusted odds ratio (AOR) was calculated by logistic regression analysis to assess the association between unintended pregnancy and CHD occurrence. The time to prepare for pregnancy and the influencing factors were also compared in this article.
Results
The risk for CHD occurrence was significantly associated with unintended pregnancy (AOR: 1.42; 95%CI: 1.16–1.73), which may increase the risks for each subtype of CHD occurrence. Risks such as parental smoking, housing renovation, accidental alcohol consumption, lack of health check-ups, and no folic acid supplementation before pregnancy were distributed differently among the planned and unintended pregnancy groups and were associated with CHD occurrence. However, there was no significant association between the duration of planned pregnancy and the risk of CHDs.
Conclusions
Unintended pregnancy increased the risk of CHDs in infants. This risk may be related to some known and unknown factors.
Synopsis
Some unintended pregnancy related factors may increase the risk for foetal CHDs. The duration of planning pregnancy may not be associated with the risk of CHDs.
摘要
目的：本研究的目的是探讨意外妊娠与婴儿先天性心脏病（CHDs）相关因素之间的关系。
方法：本文对中国7家医院1197例孤立性CHDs患者和1125例正常对照进行了多中心研究。根据妊娠意向将病例组分为计划妊娠和意外妊娠两组。通过Logistic回归分析计算调整后的优势比（AOR）, 以评估意外妊娠与CHDs发生之间的关系。并对孕期准备时间及影响因素进行了比较。
结果：CHDs的发生风险与意外妊娠显著相关（AOR：1.42；95%CI：1.16∼1.73）, 这可能增加各CHDs亚型发生的风险。父母吸烟、房屋翻新、意外饮酒、缺乏健康检查、孕前没有补充叶酸等风险在计划妊娠组和意外妊娠组中的分布不同, 与CHDs的发生有关。然而, 计划怀孕的持续时间和CHDs的风险之间没有明显的关联。
结论：意外妊娠会增加婴儿患CHDs的风险。这种风险可能与一些已知的和未知的因素有关。
概要：一些与意外妊娠相关的因素可能会增加胎儿先天性CHDs的风险。计划怀孕的持续时间可能与CHDs的风险无关。
Acknowledgements
We thank all participating families for their cooperation and for providing personal information. We thank the obstetricians, paediatricians, pathologists, experimental technicians and other participants involved in the project for recruiting the case and control participants and collecting the data.
Disclosure statement
No potential conflict of interest was reported by the author(s).