12
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Why does skin stay smooth? The dynamics of tissues in statistical equilibrium

&
Pages 311-322 | Received 16 Nov 1994, Accepted 06 Feb 1995, Published online: 27 Sep 2006
 

Abstract

The ‘molecular dynamics’ of cells in the epidermis of mammals is presented by generalizing a model of grain growth in polycrystals or coarsening foams due to Telley. The tissue remains in statistical equilibrium in spite of and because of constant renewal through local elementary topological transformations, which are division (mitosis), neighbour exchange and detachment of the cells. The global evolution and response of tissues can now be described realistically, geometrically with very few parameters and little biological input. The dynamics of cell division is modelled for the first time.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.