Abstract
Objective. The aim of our study was to assess whether the catechol-O-methyltransferase (COMT) genetic background of patients dependent on metamphetamine is related to their non-abstinence in a 1-year follow-up. Methods. We examined COMT gene Val158Met polymorphism and 1-year abstinence in a group of 31 (women N=8) Czech Caucasian metamphetamine abusers (average age, 23.8±4.0years). Results. Non-abstinence was significantly (P=0.046, Fisher's exact test) associated with the heterozygous Val/Met genotype. Conclusion. The case where subjects heterozygous for a specific genetic polymorphism show a significantly greater or lesser effect for a phenotypic trait than subjects homozygous for either allele is described as molecular heterosis in the literature. We discuss several explanations and recommendations for further research.
Acknowledgements
Supported by the Research Projects MZO 00179906 and 1M0002375201, and Grant NF/7578-3.