Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency

Abstract

Objective

We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.

Methods

Analyses were performed using non-parametric statistics to determine ΔAMSS at 6–12 monthly intervals in men on/not on TU and movement in AMSS. Factors predicting ΔAMSS were established via linear/multiple regression.

Results

TU was significantly associated with lower AMSS values compared with that at baseline/prior assessment during the initial 42 months treatment; 259 of the 260 men showed improvement. In the 361 men not on TU, AMSS values increased during 60 months of follow-up compared with that at baseline/prior assessment; improvement after 60 months was evident in 1 man, whilst AMSS remained the same or worsened in 213 and 147 men, respectively. In men on TU, baseline AMSS was inversely associated with ΔAMSS (R² = 0.97), with no other factors reaching significance. Baseline AMSS, age, serum total testosterone (TT), waist circumference (WC), and diastolic blood pressure (BP) were associated with ΔAMSS in men not on TU.

Discussion

We show that TU was associated with lower AMSS in men with adult-onset TD whilst non-treatment led to increased values. Baseline AMSS values inversely predicted ΔAMSS in both groups.

Keywords:

• Aging male symptoms score
• testosterone therapy
• metabolic syndrome
• adult-onset hypogonadism
• Wilder Effect

Disclosure statement

The authors have no competing interests to declare that are relevant to the content of this article.

Author contributions

SR, PR, and CSK: design of study, data analysis, preparation of manuscript.

AH, KSH, and FS: patient recruitment, data collection, preparation of manuscript.

PD: transposing the data, maintaining the database.

MZ, GH, AM and RCS: preparation of manuscript.

Data availability statement

All reasonable requests for data should be directed to corresponding author.

Additional information

Funding

This work was supported by North Staffordshire Medical Institute (Grant/Award Number: PID-200078). The sponsor had no role in the design of the study, statistical analysis, or presentation of manuscripts. The authors did not receive any support from any organization for the submitted work.