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Medical Mycology Volume 42, 2004 - Issue 3
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Review

Prospects of vaccines for medically important fungi
A vaccine against coccidioidomycosis is justified and attainable

G.T. Cole Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
J.-m. Xue Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
C.N. Okeke Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
E.J. Tarcha Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
V. Basrur Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
R.A. Schaller Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
R.A. Herr Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
,
J.-j. Yu Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
&
C.-y. Hung Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio, 43614, USA
 show all
Pages 189-216 | Accepted 26 Feb 2004, Published online: 09 Jul 2009
 

Abstract

Coccidioides is a fungal pathogen of humans which can cause a life-threatening respiratory disease in immunocompetent individuals. Recurrent epidemics of coccidioidal infections in Southwestern United States has raised the specter of awareness of this soil-borne microbe, particularly among residents of Arizona and Southern California, and has galvanized research efforts to develop a human vaccine against coccidioidomycosis. In this review, we discuss the rationale for such a vaccine, examine the features of host innate and acquired immune response to Coccidioides infection, describe strategies used to identify and evaluate vaccine candidates, and provide an update on progress toward development of a vaccine against this endemic pathogen.

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