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Biology and genetics

Aspergillus terreus complex

Pages S42-S46 | Received 30 Jan 2008, Published online: 17 Mar 2009
 

Abstract

Aspergillus terreus can cause invasive infections in humans, which are often refractory to therapy with the antifungal drug amphotericin B and have a propensity to dissemination. The organism has diverse colony morphology, and sub-typing studies have demonstrated that isolates of A. terreus are diverse in their genotypes. However, detailed phylogenetic studies of section Terrei employing sequence information from protein coding regions have not been thus far attempted. Interestingly, A. terreus produces unicellular forms called accessory conidia in vitro and during infection; the clinical relevance of these structures are not well understood. This paper presents an overview of the morphology, species identification strategies, and molecular epidemiology of A. terreus.

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