Impaired decision-making under risk in patients with functional dyspepsia

ABSTRACT

Introduction

The cognitive processing in patients with functional dyspepsia (FD) has not been well established. Decision-making is an important component of cognitive function. Most brain regions involved in decision-making are abnormal in FD patients. This study aimed to investigate the decision-making under ambiguity and risk in FD patients.

Methods

We recruited 40 FD patients meeting Rome III criteria and 40 healthy controls (HCs) matched for age, sex, marital status, and education level. The Hamilton Anxiety Scale (HAMA) and the 17-item Hamilton Depression Scale (HAMD-17) were used to evaluate their anxiety and depression emotions. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT) were used to evaluate decision-making under ambiguity and risk, respectively. Helicobacter pylori status, disease duration, dyspeptic symptom score, and the Nepean Dyspepsia Life Quality Index (NDLQI) were obtained from all patients.

Results

In IGT, FD patients had a lower total net score, chose more adverse choices, and showed a slower response to change their behavior than HCs. However, there was no significant difference in the net score of the first 2 blocks between the two groups. In GDT, FD patients had a lower total net score, higher risk score, and lower use of negative feedback than HCs. In addition, FD patients showed better GDT performance than those without early satiation.

Conclusions

FD patients showed impaired decision-making under risk. The deficiency might be related to dyspeptic symptoms of FD patients.

KEYWORDS:

• Functional dyspepsia
• decision-making
• dyspeptic symptoms
• Iowa Gambling Task
• Game of Dice Task

Acknowledgments

We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Scientific Research Foundation for Ph.D. of the Second Affiliated Hospital of Anhui Medical University [2018BSJJ054], Natural Science Research Projects in the Anhui Universities [KJ2019A0268] and the basic-clinical cooperation research program of Anhui Medical University [2019xkjT012].