Individual Contribution of Youth Antisocial Symptoms to Suicide Behavior in Adults with Substance Use Disorders

Abstract

This study assesses the individual contribution of youth symptoms of antisocial personality disorder (before the age of 15) in past-month suicidal behavior in adults with substance use disorders. Youth antisocial symptoms and suicidal behavior were assessed using the Mini International Neuropsychiatric Interview. Indicators of youth antisocial symptoms were significantly associated with suicide outcomes; lack of remorse (OR = 2.68 CI 95% 1.37, 5.25), and sexual assault with planning, and destruction of property to attempt (OR = 4.22 CI 95% 1.29, 15.08). Our results suggest that specific antisocial indicators during adolescence could be associated with suicide in adulthood, even after controlling for major depressive disorder. Further implications for the research of antisocial symptoms and suicide behavior from a developmental perspective are discussed.

Keywords:

• antisocial personality disorder
• substance use disorder
• suicidal behavior
• suicide attempt

Acknowledgments

The authors express their gratitude to the following institutions for their support in this study: Florida Node Alliance Miller School of Medicine, National Institute on Drug Abuse–Clinical Trials Network (NIDA-CTN), Consejo Nacional Contra las Adicciones (CONADIC-México), Instituto para la Atención y Prevención de las Adicciones en la Ciudad de México Instituto, Mexiquense Contra las Adicciones, Consejo Estatal Contra las Adicciones de Puebla, Consejo Estatal Contra las Adicciones de Hidalgo, Consejo Estatal Contra las Adicciones de Querétaro. We also wish to thank David Sheehan for allowing the use of the Spanish-language adaptation of the fifth version of the Mini International Neuropsychiatric Interview in Spanish.

Additional information

Funding

This publication stems from the project “Development of a Clinical Trial Network on Addiction and Mental Health in Mexico,” funded by a grant from the U.S. Department of State (Grant No. SINLEC11GR0015-A001). The U.S. Department of State had no role in the study design, collection, analysis, or interpretation of the data, writing the manuscript, or the decision to submit this paper for publication. Also Sonia Pérez-Matus received funding from The National Council of Science and Technology of Mexico through a master degree grant no. 778596.

Notes on contributors

Luis Villalobos-Gallegos

Luis Villalobos-Gallegos, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM). Unidad de Ensayos Clínicos en Adicciones y Salud Mental, Ciudad de México, México.

Sonia Pérez-Matus

Sonia Pérez-Matus, Instituto Nacional de Salud Pública (INSP). Centro Colaborador de la OPS/OMS para la Investigación de Lesiones y Violencia del INSP, Cuernavaca, Morelos.

Rosario Valdez-Santiago

Rosario Valdez-Santiago, Sonia Pérez-Matus, Instituto Nacional de Salud Pública (INSP). Centro Colaborador de la OPS/OMS para la Investigación de Lesiones y Violencia del INSP, Cuernavaca, Morelos.

Rodrigo Marín-Navarrete

Rodrigo Marín-Navarrete, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (INPRFM). Unidad de Ensayos Clínicos en Adicciones y Salud Mental, Ciudad de México, México.