Cytoprotective and antioxidant effects of the red alga Alsidium corallinum against hydrogen peroxide-induced toxicity in rat cardiomyocytes

Abstract

Context: Sepsis is the manifestation of the immune and inflammatory responses to infection that may ultimately result in multiorgan failure. Many substances are involved in myocardial dysfunction in sepsis, including hydrogen peroxide.

Objective: This study evaluates the protective activity of the red alga Alsidium corallinum against hydrogen peroxide (H₂O₂)-induced toxicity in H9c2 cardiomyocytes.

Material and methods: The biological properties of A. corallinum were firstly investigated. Secondly, the H9c2 cells were pre-treated with alga extract, and then exposed to H₂O₂.

Results: Our results showed richness of the alga in antioxidant compounds, and its biological activities. H₂O₂ induced a morphological changes and decrease in H9c2 cell viability correlating with an increase in enzymatic and non-enzymatic antioxidants. Pre-treatment with A. corallinum, reduces toxicity and decreased the antioxidants status induced by H₂O₂.

Conclusion: These findings indicated for the first time the protective effect of A. corallinum against H₂O₂-induced toxicity in H9c2 cells.

Keywords:

• Alsidium corallinum
• cardiomyocytes cell
• hydrogen peroxide
• antioxidant activities

Disclosure statement

The authors declared that they have no competing interests.

Additional information

Funding

The present work was supported by grants from the DGRST [Direction Générale de la Recherche Scientifque et Technique-Tunisie. Appui à la Recherche Universitaire de base UR/12 ES-13].