High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome

Abstract

This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VO₂max), and lipid profile were assessed before and after HIIT. Serum or plasma levels of cytokines and hormonal markers were measured along the intervention. The analysis of messenger RNA (mRNA) expression of these cytokines was performed in peripheral blood mononuclear cells (PBMC). VO₂max and some anthropometric parameters were improved after HIIT, while decreased levels of proinflammatory markers and increased levels of interleukin-10 (IL-10) were also found. Adipokines were also modulated after 12 weeks or training. The mRNA expression of the studied genes was unchanged after HIIT. In conclusion, HIIT benefits inflammatory and hormonal axis on serum or plasma samples, without changes on PBMC of postmenopausal MS patients.

Keywords:

• Metabolic syndrome
• obesity
• adipokines
• mRNA
• high-intensity interval training

Acknowledgements

We greatly appreciate the people involved in data collection, as well as project participants. We thank Clinimagem crew for all assistance with densitometry data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

J.B.F. and S.T.S. received fellowship from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). F.A.A.S. received a fellowship from CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).