Abstract
Omentin-1 is a novel adipokine with anti-inflammatory functions. Apelin is associated with hyperinsulinemia and pathological angiogenesis. Chemerin has both pro- and anti-inflammatory actions and implicated in insulin resistance and metabolic syndrome. The aim of this study was to assess serum omentin-1, apelin and chemerin concentrations and to investigate their association with the presence and severity of DR in T2DM patients. Serum omentin-1, apelin and chemerin were measured in 112 patients with DR and 56 patients without DR. Bivariate analysis showed omentin-1 correlated negatively with hsCRP and TyG index; while apelin correlated positively with chemerin. Linear regression data showed that apelin and chemerin were independent predictors of DR severity. ROC curve revealed that omentin-1 was the best discriminant for DR while apelin was the best discriminant for vision threatening retinopathy. Serum omentin-1 concentration correlates negatively, while serum apelin and chemerin concentrations correlate positively with DR presence and severity in T2DM patients.
Acknowledgements
The authors thank Postgraduate Research Monitoring Committee of JIPMER for approval and support.
Ethical approval
The institute ethics committee (Reg. No: ECR/342/Inst/PY/2013) of JIPMER approved this study (Ethics certificate No.: JIP/IEC/2016/27/907).
Contributorship
MY and GPS researched literature and conceived the study. MY, GPS, KJ, KRB and MV were involved in protocol development, gaining ethical approval and patient recruitment. MY, KJ, PC and GPS were involved in sample processing and data analysis. MY and KJ wrote the first draft of the manuscript. GPS helped in reviewing and writing the final manuscript. All authors reviewed the manuscript and approved the final version of the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.