Expression analysis of inflammatory response-associated genes in coronary artery disease

Abstract

Background

Coronary artery disease (CAD) is among prominent causes of death throughout the world. Inflammatory processes participate in the pathogenesis of this disorder.

Methods

In the current case–control study, we compared expression levels of three inflammation-associated genes namely Antisense noncoding RNA in the INK4 locus (ANRIL), NKILA and IL-1B between CAD patients and matched healthy subjects.

Results

ANRIL, IL-1B and NKILA were significantly down-regulated in CAD patients compared with controls (p values of <.0001, .023 and <.0001, respectively). When evaluating study participants based on their gender, the differences in expression levels of ANRIL and NKILA were significant in both male and female patients compared with the matched controls. However, IL-1B was only down-regulated in female patients compared with female controls.

Conclusion

Taken together, our study revealed dysregulation of inflammation-associated genes in the peripheral blood of CAD patients and supported the previously suggested role of inflammation in the pathogenesis of CAD.

Keywords:

• Coronary artery disease
• antisense noncoding RNA in the INK4 locus
• ANRIL
• NF-κB interacting long noncoding RNA
• NKILA
• IL-1B
• lncRNA

Disclosure statement

The authors declare they have no conflict of interest.

Additional information

Funding

The current study was supported by a grant from Shahid Beheshti University of Medical Sciences.