Effects of aminophylline on the levels of neutrophil gelatinase-associated lipocalin (NGAL) in asphyxiated term neonates

Abstract

Objective

Our study evaluates the effects of aminophylline in the reduction of NGAL levels in perinatal asphyxia.

Methods

Term neonates with hypoxic ischaemic encephalopathy who were divided into two groups, the treatment and placebo. Urine NGAL levels were measured on day one and four of the treatment using BIOPORTO kits in both the groups.

Results

Day 1 NGAL levels were not statistically different in either group irrespective of the age, gender and the mode of delivery. on 4^th day, NGAL in treatment group significantly decreased as compared to day 1 levels and placebo day-4 levels. significant differences were seen between first and fourth day NGAL levels among children with normal and caesarean birth and among female and male neonates.

Conclusions

Following the treatment with aminophylline, NGAL levels in asphyxiated neonates are likely to reduce. Further studies based on other kidney dysfunction parameters can lead to the better and accurate conclusions.

Keywords:

• NGAL
• aminophylline
• renal failure
• asphyxiated neonates

Disclosure statement

The authors deny any conflict of interest in any terms or by any means during the study. All the fees provided by research centre fund and deployed accordingly.