Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis

Abstract

This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p = .007) and AT genotypes (p = .04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.

Keywords:

• The fat mass and obesity associated
• FTO
• body fat
• polymorphism

Ethics approval

The present study was approved by the Ethics Committee of Guilan University of Medical Sciences (IR.GUMS.REC.1398.273).

Acknowledgements

This article is adapted from a research project approved by the Student Research Committee of Guilan University of Medical Sciences, Rasht, Iran (code 98050510). All colleagues in this university are warmly appreciated for their support and contribution.

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.