The effect of nutrition and exercise training on irisin and semaphorin-3E levels in obese patients

Abstract

We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individuals. Nutrition and exercise training were applied to groups for eight weeks. Insulin resistance decreased in non-obese and 1st degree obese subjects. HsCRP values decreased only in the second degree obese individuals. Adiponectin values were significantly decreased in all three groups. There was a negative correlation between serum adiponectin and plasma irisin levels both before and after treatment. Sema-3E levels increased significantly in only the first degree obese individuals, whereas plexin-D1 values did not change significantly in any group. Our findings indicate that nutrition and exercise training we apply improved both anthropometric measurements and biochemical parameters in obese and non-obese individuals.

Keywords:

• Nutrition
• insulin resistance
• irisin
• obesity
• Sema3E
• biomarker

Compliance with ethical standards

The study was approved by Eskisehir Osmangazi University Clinical Research Committee with the decision dated 10.08.2017 and numbered 80558721/212.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This study was supported by Eskişehir Osmangazi University Scientific Research Projects Commission. [Project No: 2018–2085].