Percentages of serum, liver and adipose tissue fatty acids and body weight are affected in female rats by long-term Central kisspeptin treatments

Abstract

This study was conducted to determine the possible effects of long-term exogenous kisspeptin and its antagonist P234 on serum, liver and adipose tissue fatty acids (FA) profiles, as well as body weight, in female rats. Kisspeptin (50 pmol) and P234 (1 nmol) were administrated to the weaned Sprague–Dawley female rats by an intracerebroventricular injection from the 26th postnatal day to the 60th postnatal day. Percentages of the serum total saturated FA (∑SFA) and total monounsaturated FA (∑MUFA) were lower in the kisspeptin group. In the adipose tissue, ∑SFA was lower and total unsaturated FA higher in the P234 group. Moreover, long-term central kisspeptin injection caused a decrease in the body weight. When compared to the kisspeptin group, the final body weights were higher in the P234 and kisspeptin + P234 groups. According to our results, we suggest that kisspeptin has a regulatory role in FA metabolism and regulation of body weight.

Keywords:

• Kisspeptin
• kisspeptin antagonist
• fatty acids
• body weight
• energy metabolism
• rat

Disclosure statement

The authors declare no conflict of interest.

Author contributions

ZS and HK conceived the study idea; MO, AO, SC and SK contributed to the study design. All authors contributed towards data collection. ZS, MO and HK analysed the data and wrote the manuscript. All authors discussed the data and approved the submitted draft. ZS takes responsibility for the integrity of the study.

Data availability statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study (Data sharing not applicable – no new data generated).

Additional information

Funding

This study was supported by the Scientific and Technological Research Council of Turkey [TUBITAK, Project no: 113S193].