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Ophthalmic Genetics Volume 28, 2007 - Issue 2
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RESEARCH ARTICLE

Intron 4 VNTR of Endothelial Nitric Oxide Synthase (eNOS) Gene and Diabetic Retinopathy in Type 2 Patients in Southern India

Satagopan Uthra SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India
,
Rajiv Raman Shri Baghawan Mahavir Vitreo-Retinal Services, Chennai, India
,
Bickol N. Mukesh Sankara Nethralaya Diabetic Retinopathy Project, Medical & Vision Research Foundations, Chennai, India
,
Padmaja Kumari R Shri Baghawan Mahavir Vitreo-Retinal Services, Chennai, India
,
Pradeep G. Paul Sankara Nethralaya Diabetic Retinopathy Project, Medical & Vision Research Foundations, Chennai, India
,
Praveena Lakshmipathy SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India
,
Perumal Gnanamoorthy Sankara Nethralaya Diabetic Retinopathy Project, Medical & Vision Research Foundations, Chennai, India
,
Tarun Sharma Shri Baghawan Mahavir Vitreo-Retinal Services, Chennai, India
,
Catherine A. McCarty Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
&
Govindasamy Kumaramanickavel SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai, India
 show all
Pages 77-81 | Received 10 Jan 2007, Accepted 10 Jan 2007, Published online: 08 Jul 2009
 
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Abstract

A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR−) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

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Related Research Data

The Role of Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene in Diabetic Retinopathy in a Tunisian Population
Source: Informa UK Limited
Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians
Source: Springer Science and Business Media LLC
ENOS polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Chinese Han population.
Source: Informa UK Limited

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