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ABSTRACT
Since cutoff scores are necessary for differentiating normal cognitive functioning from dementia, the main objective of this study was to establish normative data of the K-T test, a standardized cancellation test. The construct validity of K-T test was also investigated. In total, 2471 cognitively intact elderly subjects from the SU.VI.MAX 2 study were included in the present study. Younger subjects, women and subjects with higher education had a higher number of correct answers and fewer omission errors. Participants made few commission errors and only the educational level was found to have a significant effect. Normative data for correct responses and efficiency were stratified by age, education, and gender. Correlation analysis showed that the K-T test was significantly correlated to validated neuropsychological tests assessing executive functions. This study permits to strengthen the utility of the K-T test to detect impairment of the executive components involved in the task.
Acknowledgments
This work was granted by the ANR (no. ANR-05-PNRA-010), DGS (Ministry of Health) and supported by the Médéric, Sodexo, Ipsen, MGEN and Pierre Fabre. Mederic and MGEN are French health insurance organizations which are complementary to the national health insurance system. Ipsen and Pierre Fabre are private pharmaceutical companies. They financially support overall implementation of the research project. Sponsors were not involved in analysis or interpretation of findings. We thank all scientists, dieticians, technicians, and assistants who helped carry out the SU.VI.MAX 2 study. We especially thank Stéphane Raffard, neuropsychologist, who was responsible for standardization of cognitive evaluation, Nathalie Arnault, and Laurent Bourhis (statistician) who coordinated data management, Frédérique Ferrat who coordinated operational aspects of neuropsychological evaluation and Gwenael Monot (computer scientist) who coordinated the computing aspects. Finally, we thank Laila Kamali for editing and proofreading the manuscript.