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Aging, Neuropsychology, and Cognition
A Journal on Normal and Dysfunctional Development
Volume 3, 1996 - Issue 2
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Original Articles

Definition, course, and outcome of mild cognitive impairment

Glenn E. Smith
,
Ronald C. Petersen Mayo Clinic, Rochester, Minnesota
,
Joseph E. Parisi Mayo Clinic, Rochester, Minnesota
,
Robert J. Ivnik Mayo Clinic, Rochester, Minnesota
,
Emre Kokmen Mayo Clinic, Rochester, Minnesota
,
Eric G. Tangalos Mayo Clinic, Rochester, Minnesota
&
Stephen Waring Mayo Clinic, Rochester, Minnesota
 show all
Pages 141-147 | Accepted 27 Nov 1995, Published online: 25 Sep 2007
 
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Abstract

Mild Cognitive Impairment (MCI) is a term which can be applied to a boundary area between dementia and normal aging. Criteria which reliably describe persons falling in this range of the cognitive continuum can be defined. These persons are at very high risk for developing dementia. Biologic and cognitive parameters including Apolipoprotein E genotype help to differentiate MCI persons who will progress to dementia in 2-4 years from those who will remain free from dementia over this interval.

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