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Research Article

Chemical Constituents and Analgesic Activity of Conocliniopsis prasiifolia.

Jackson Roberto Guedes da S. Almeida Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

Marcelo Sobral da Silva Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

Emidio Vasconcelos L. da-Cunha Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil; Departamento de Farmácia, Universidade Estadual da Paraíba, CCBS, Campina Grande, Paraíba, Brazil

Petrônio Filgueiras de Athaíde-Filho Departamento de Ciências Básicas Sociais, DCBS, Universidade Federal da Paraíba, Bananeiras, Paraíba, Brazil

Margareth de F.F. Melo Diniz Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

Maria das Graças da Silva Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

Orlando Seiko Takemura Laboratório de Farmacologia, Universidade Paranaense, Umuarama, Paraná, Brazil

José Maria Barbosa-Filho Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil

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ABSTRACT

The phytochemical study of Conocliniopsis prasiifolia. (DC) R. M. King & H. Robinson (Asteraceae) yielded four substances which were identified by spectral analysis as the flavonoids 5-hydroxy-4′,7-dimethoxyflavone, 4′,5,6,7-tetramethoxyflavone, 4′,5,7-trimethoxyflavone and 4′,5-dihydroxy-7-methoxyflavone, described here for the first time in this species. The evaluation of analgesic activity of the crude extract, carried out by the hot plate test in mice, suggests a potent antinociceptive effect.

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Notes

*p < 0.05, n = 3, test experiment.

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Related Research Data

Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance

Source: Molecular Diversity Preservation International

Flavonoids of Artemisia tenuisecta

Source: Springer Science and Business Media LLC

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Chemical Constituents and Analgesic Activity of Conocliniopsis prasiifolia.

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