Central Antinociceptive Effects of Cissus sicyoides. on Mice

Abstract

The acute and chronic treatment of mice with a hydroalcohol extract from the leaves of Cissus sicyoides. L. (Vitaceae) (CS) at doses of 300, 600, and 1000 mg/kg, by intraperitoneal administration, produced a significant central antinociceptive effect on the hot plate, tail immersion, and acetic acid–induced writhing, tests, and the effect was inhibited by naloxone. CS was given to mice daily for 30 days at a dose of 600 mg/kg, causing an effect similar to that of drugs with typical action on opioid receptors. The effective dose (ED₅₀) was approximately 600 mg/kg in mice.

Keywords:

• Analgesic effect
• Cissus sicyoides
• CNS activity
• morphine
• naloxone