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Abstract
This study was undertaken to evaluate the effect of topical administration of Rubus suavissimus. S. Lee (Rosaceae) (RUS), an extract of Chinese sweet leaf tea, in the prevention of experimentally induced corneal neovascularization. Corneal neovascularization was induced in 40 rat eyes (1 per animal) by a silver nitrate cauterization technique. Three concentrations (0.1%, 1%, and 10% w/v) of RUS in saline were administered topically twice a day for 7 days. The coverage of the corneal surface by neovascular vessels was measured, using photographs, as a percentage of total cornea area. A histopathologic score was assigned to each cornea. The difference in mean burn stimulus scores of treatment and placebo groups was not statistically significant (p = 0.714). The 10% RUS solution caused a significant decrease in the percentage of neovascularization in response to cauterization (p < 0.01); the 0.1% and 1% concentrations were not significantly different from controls (p = 0.173). The 10% concentration group had significantly less neovascularization than the control group (p < 0.01). It was found that topical application of 10% RUS solution caused a significant decrease in neovascular response to silver nitrate cauterization compared with control eyes.