Phytochemical Analysis and Antifungal Evaluation of Sebastiania commersoniana. Extracts

Abstract

The 50% ethanol extract from Sebastiania commersoniana. (Baill.) L.B. Sm. & B.J. (Euphorbiaceae), a South American medicinal plant locally used as external antiseptic, was subjected to a phytochemical study and to the determination of its in vitro. antifungal activity. After fractionation of the extract, four flavonoids (quercetin, kaempferol, isorhamnetin, isoquercitrin), four phenolic derivatives (gallicin, gallic, syringic, and caffeic acids), and a coumarin (scopoletin) were identified. The structures of isolated compounds were established by spectroscopic methods and confirmed by comparison with reference samples and literature data. The extract exhibited significant antifungal activity against the dermatophytes Microsporum gypseum., Trichophyton mentagrophytes. and Trichophyton rubrum..

Keywords:

• Antifungal activity
• isolated compounds
• plant extracts
• Sebastiania commersoniana