Effect of myricetin on behavioral paradigms of anxiety

Abstract

Myricetin (10, 30, and  100 mg/kg) obtained from Vitis vinifera Linn. (Vitaceae) exhibited significant anxiolytic activity in behavioral models of anxiety, namely, elevated plus maze, light/dark apparatus, open field apparatus, and hole board apparatus, in mice. Myricetin significantly (p < 0.05) reduced lithium induced head twitches and also antagonized meta-chlorophenylpiperazine (m-CPP) induced anxiety, suggesting that it acts by modifying serotonin transmission. The cumulative concentration response curve (CCRC) of 5-HT in the presence of myricetin (10 μg/mL) was shifted toward the right in rat fundus.

Keywords::

• Anxiety
• myricetin
• serotonin
• m-CPP
• behavioral paradigms

Declaration of interest: The authors alone are responsible for the content of this paper.