Abstract
The phytochemical investigation of the ethyl acetate soluble fraction of the dried floral buds of Syringa patula palibiniana Nakai (Oleaceae) has led to the isolation of six compounds: β-amyrin acetate (1), β-sitosterol (2), nortropin (3), eugenol (4), syringaresinol (5), and oleoside 11-methyl ester (6). The structures were elucidated by spectroscopic and chemical means. Investigation of the biological activities indicated that 5 and 6 possessed a strong cytotoxic activity against Hep-G2 cells; 1 and 5 remarkably increased the macrophage proliferation index; 1 and 5 exhibited high anti-inflammatory activities as indicated by inhibited LPS-induced NO generation; and only 5 showed a strong scavenging activity against DPPH. Taken together, results indicate that 5 is a multipotent compound active as an anti-cancer, immunoproliferative, anti-inflammatory, and antioxidant agent.
Acknowledgements
The authors wish to thank the Department of Forest Products, College of Forest Science, Kookmin University, South Korea for providing and botanical identification of the plant, and Professor Young-Kyoon Kim, College of Forest Science, Kookmin University, South Korea for his cooperation and assistance.
Declaration of interest: This work was financially supported by the National Research Center, Cairo, Egypt.