Histological Investigations of Toxocora Canis Tissues and their Micromorphological Changes Under the Action ofAlbendazole in vivo

Abstract

The article presents the results of the histological investigations of the tissues of Toxocara canis in norm and their changes under the in vivo, action of albendazole, one of benzimidazoles. Material for histological and pathohistological investigations was obtained from naturally infected with T. canis one-month-old puppies. T. canis nematode that were eliminated from the host intestine were histologically investigated in 19-21, 32-33, 37-38, 46, and 54 hours onset the treatment. Micromorphological investigations of the changes in the tissues and organs of T. canis have shown that under the action of albendazole, first of all, cytoskeleton of epithelial cells of the intestine and sexual tubes is harmed. Afterwards, muscle cells, hypodermis and cuticle change. The effect of albendazole on mature and premature eggs has also been determined. No changes in the nerve cords have been observed.

Keywords:

• Toxocara canis
• histology of nematodes
• albendazole
• benzimidazoles