Abstract
The paper explored the application of psychological contract in HIV prevention clinical trials in resource poor communities in Africa. The psychological contract was discussed in relation to practices in New HIV Prevention Technologies in Africa. From this discussion, it would seem risk for exposure to HIV infection is less well articulated in the psychological contract between the promoters of HIV prevention clinical trials and participants in resource poor communities in Africa. The trialing of New HIV Prevention Technologies in Africa should have in-built psychological contract transparency to reduce the risk of participant exposure to HIV infection in clinical trials.