Inflammatory markers: linking unstable plaques to coronary event, an interventional perspective

Abstract

Abundant data links inflammatory mechanisms to atheromatous plaque destabilization leading to plaque rupture and coronary events. The discovery of inflammatory cells and inflammatory mediators within atherosclerotic plaques prone to rupture led to a series of studies demonstrating an association between various markers of inflammation and future coronary events. Inflammatory markers have also been used in patients undergoing coronary angioplasty in an attempt to predict restenosis and risk for post-procedural coronary events. This review article provides an overview on the potential use of inflammatory markers in the context of coronary interventions. (Int J Cardiovasc Intervent 2004; 6: 110-118)

• acute coronary syndromes
• atherothrombosis
• biological markers
• C-reactive protein
• vulnerable plaque