Oocyte yield in social, medical and donor oocyte cryopreservation cycles

Abstract

To determine if oocyte yield in women undergoing cryopreservation for social (SOC), medical (MOC) and oocyte donation (OD) cycles is comparable when matched for age. 315 oocyte retrievals were performed for SOC, 116 for MOC and 392 for OD. Non-parametric Kruskal-Wallis tests and Poisson regression were used to assess the impact of age stratification. The median ages of women undergoing SOC, MOC, and OD were 38, 31 and 26 years respectively. The median (IQR) number of oocytes in the three categories was 7, 10, and 12. The oocyte yield was significantly higher in women aged 30–34 years undergoing SOC, compared to the MOC group. For the SOC group, age in years, oestradiol levels per 1000 pmol/and follicle count >12mm on the day of trigger were significant predictors of oocyte yield. Women embarking on SOC are significantly older than those undergoing MOC and OD, and thus oocyte yield is reduced when stratified for age. This study highlights the significant predictors of oocyte yield amongst women undergoing oocyte cryopreservation for specific indications. The findings can be used to optimise the yield and overall chance of successful livebirth.

Keywords:

• Social
• medical oocyte cryopreservation
• donation
• vitrification
• oocyte yield

Acknowledgements

JBN was involved in conceiving the study and writing the first draft of the manuscript which was revised by LSK, BPJ and SS. GN and JG were involved in the data collection, AP carried out statistical analysis and PS and EY were involved in critique of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).