An update on the pharmacotherapeutic strategies for the treatment of dysthymic disorder: a systematic review

ABSTRACT

Introduction

Longer treatment times, more comorbidity, more severe impairments in social, psychological, and emotional functioning, increased healthcare use, and more hospitalizations are all factors that are related to dysthymia. Given the significant prevalence of dysthymia (including persistent depressive disorder) worldwide, its comorbidity with several mental disorders, and the detrimental effects of these comorbidities, it is important to conduct a systematic review to compare the effects of pharmacological acute and maintenance treatments for dysthymia with placebo and standard care in the last 10 years, based on the publication of DSM5.

Areas covered

This systematic review was performed according to PRISMA guidelines. Databases, including PubMed and Cochrane Central Register of Controlled Trials, were searched to assess the effects of pharmacological acute and maintenance treatments for dysthymia in comparison with placebo and treatment as usual.

Expert opinion

Our review shows that SSRIs and SNRIs present efficacy for dysthymia treatment, and L-Acetylcarnitine should be investigated further for this condition in elderly patients. The comparison of antidepressant medication versus placebo showed coherent results based on three studies favoring pharmacotherapy as an effective treatment for participants with dysthymia. However, the scarcity of research on continuation and maintenance therapy in people with dysthymia highlights the need for more primary research.

KEYWORDS:

• Chronic depression
• L-Acetylcarnitine
• persistent depressive disorder
• SSRI
• antidepressant

Article highlights

• Dysthymic disorder (DD) denotes chronic depression.

• Dysthymia is highly prevalent worldwide, and leads to severe impairments in social, psychological, and emotional functioning.

• This systematic review compared the effects of pharmacological treatments for dysthymia.

• SSRIs and SNRIs present efficacy for dysthymia treatment.

• L-Acetylcarnitine should be investigated further for this condition in elderly patients.

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.