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Review Article

Motor protein diseases of the nervous system

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Pages 197-201 | Received 28 Sep 2004, Accepted 22 Feb 2005, Published online: 10 Jul 2009
 

Abstract

Motor proteins link concepts of impaired axonal transport with concepts of impaired energy metabolism in motor neuron disease. Thus it is not surprising that in recent years several reports on the relevance of motor protein function in mice models for motor neuron disease as well as motor neuron patients have appeared. This article summarizes the broad spectrum of neurological phenotypes, which are caused by alterations of motor protein function. This is likely to add to the understanding of motor neuron disease and may be relevant in terms of future therapeutic approaches.

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