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Abstract
Since the evaluation of vital capacity (VC) needs to be carried out every three months in patients with amyotrophic lateral sclerosis (ALS), a portable spirometer would be of value in clinical practice. Over the follow‐up of 52 ALS patients, we compared the values of slow vital capacity measured by two spirometers: a reference flow‐metered spirometer based on a Hans‐Rudolph pneumotachograph and a portable Venturi spirometer. The objectives were to analyse the overall concordance of the measurements from the two devices and determine a discordance cut‐off. The correlation between measurements was high (r = 0.936) and significant (p<10−20). Bland and Altman analysis showed that the measurements were concordant at a statistical risk of 5%; nevertheless, on examination of the raw differences between the measurements, two sub‐populations could be identified on either side of the 56% cut‐off where the means of the differences were significantly different (p<0.0001). The 56% cut‐off was also statistically significant in plotting differences against the coefficient of variations of the data pairs expressed as (100×s/mean). The differences observed between the two spirometers could be explained by technical differences between the devices as well as by an increase in variability with progression of the disease. In conclusion, this study demonstrates that a portable spirometer can be used reliably at the bedside. For values of vital capacity below the discordance cut‐off of 56%, vital capacity should be determined by operators trained in pulmonary function examinations.