Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment

ABSTRACT

Nanotechnology has been extensively utilized in the design and development of powerful strategies for drug delivery and cancer theranostic. Nanoplatforms as a drug delivery system have many advantages such as in vivo imaging, combined drug delivery, extended circulation time, and systemic controlled release. The functional biomimetic drug delivery could be realized by incorporating stimuli-responsive (pH, temperature, redox potential, etc.) properties into the nanocarrier system, allowing them to bypass biological barriers and arrive at the targeted area. In this review, we discuss the role of internal stimuli-responsive nanocarrier system for imaging and drug delivery in cancer therapy. The development of internal stimuli-responsive nanoparticles is highlighted for precision drug delivery applications, with a particular focus on in vivo imaging, drug release performance, and therapeutic benefits.

Graphical Abstract

KEYWORDS:

• Functional nanoparticles
• drug delivery
• theranostics
• stimuli-responsive

CLASSIFICATION:

• 10 Engineering and Structural materials
• 211 Scaffold / Tissue engineering / Drug delivery

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Major State Basic Research Development Program of China [Grant Nos. 2017YFA0205201; 2014CB744503; 2013CB733802], the National Natural Science Foundation of China (NSFC) [Grant Nos. 81801817; 81422023; 81371596;51273165;U1705281;U1505221], the Program for New Century Excellent Talents in University [NCET-13-0502], and the Fundamental Research Funds for the Central Universities, China [20720150206; 20720150141].