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ABSTRACT
This is a preliminary study of a material comprising gelatin (Gel), silver nanoparticles (AgNPs) and curcumin (Cur) aimed for wound-healing treatment. Gelatin was used to stabilize AgNPs and encapsulate curcumin to form a therapeutic composite (GelCurAg) for their strong bactericidal and antioxidant properties. GelCurAg formulations with different gelatin concentrations were characterized to attain information about their physiochemical properties and the loading efficiency of therapeutic agents. In vitro assessment of GelCurAg focused on antibacterial, antioxidant and cytotoxic aspects. The results suggested that Gel1CurAg (synthesized from 1% gelatin solution) could be utilized as potential therapeutic agents in treating infectious wound owing to its bactericidal and antioxidant effects and low toxicity for clinical uses.
GRAPHICAL ABSTRACT
Acknowledgments
We would like to express our gratitude to Nafosted Vietnam Funding for their support. We would also like to thank Mr. Nguyen Kien Phuc for his advice in the fabrication of nanoparticles, Ms. Tra Thanh Nhi, Ms. Do Bui Thuan Thien and Ms. Tran Thi Phuong Trang for their guidance in antibacterial assays and the support of Ms. Vo Minh Thuy throughout this study.
Disclosure statement
No potential conflict of interest was reported by the authors.
