HIV Pol: does it offer therapeutic targets for HIV?

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Article highlights

• Advances in knowledge of the structure of HIV Pol may contribute to the development of antiretroviral strategies.

• The dimerization of reverse transcriptase has a profound effect on the maturation of HIV pol precursors.

• An approach targeting CARD8 inflammasome activation combined with a ‘shock and kill’ scheme may be explored for an HIV cure trial.

• Because Pol is a highly conserved region of the HIV genome, it can be targeted by CRISPR-Cas technology and designed for HIV vaccine.

Abbreviations

PR, protease; RT, reverse transcriptase; IN, integrase.

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.