Assessment of the properties of the EQ-5D-5L in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

ABSTRACT

Objective

This study systematically reviews the validity, reliability, and responsiveness of the EQ-5D-5 L in studies of T2DM.

Methods

Relevant articles were retrieved by searching four databases, namely, the Web of Science, Scopus, PubMed, and Cochrane Library up to November 2020 with English language. All stages of the review conducted by two authors and disagreements were solved by consultation with a third reviewer.

Results

Of the 1614 identified studies, 46 were remained for review. The EQ-5D-5 L mean scores ranged from 0.314 (0.4) (n = 141) for diabetic patients undergoing hemodialysis to 0.971 (0.082) (n = 56) for diabetic patient without retinopathy. Mean EQ-5D-5 L scores in men (0.847) were higher those in women (0.747). Construct validity and reliability was confirmed in the studies that reported the properties of the EQ-5D-5 L, and responsiveness reported in a study that was good. There were ceiling effects in seven studies. The overall utility value was higher in Japan (0.86, 95% CI: 0.80–0.92, p = 0.0001) thanCanada (0.79, 95% CI: 0.78–0.80, p = 0.81), and the United Kingdom (0.72, 95% CI: 0.64–0.79, p = 0.0001).

Conclusion

Findings demonstrated validity, reliability of the EQ-5D-5 L in T2DM and the existence of ceiling effects. However, the assessment of responsiveness and sensitivity needs further observations.

KEYWORDS:

• Utility
• type 2 diabetes mellitus
• EQ-5D-5L
• psychometrics properties

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Author contributions

H Ameri, and S Afshari contributed to conception and design. H Ameri, S Afshari, and S Baharinya contributed to screen the records, data extraction, and quality appraisal. M Arab-Zozani and H Ameri contributed to data analysis. H Ameri, and M Mojahedian contributed to draft manuscript. S Afshari and H Ameri contributed to critical review. All authors approved the final version of the manuscript for publication.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This paper was not funded.