Cytotoxic Bis-3,4-dihydro-β-carbolines and Bis-β-carbolines

Abstract

Ten bis- β -carboline 1, 2 and bis-3,4-dihydro- β -carboline 3, 4 derivatives, linked between carbons 1 and 1′ by a polymethylene spacer, were synthesized from bis-tryptamine amides 9, 10. Some of them display a micromolar IC 50 towards L-1210 cells.

Keywords::

• Bis-β-carboline
• Bis-3,4-dihydro-β-carboline
• Cytotoxic Activity