Abstract
We identified 6-deoxy-homoDMDP as a potent inhibitor of chitin synthase (Ki=38 μM), displaying an uncompetitive inhibition pattern. Dual inhibition was also performed with the enzymatic reaction product uridine 5′-diphosphate in order to evaluate the concurrent effect of both inhibitors. An interaction coefficient α of 0.9 was found, revealing synergistic inhibition.