Inhibition of potassium bromate-induced renal oxidative stress and hyperproliferative response by Nymphaea alba in Wistar rats

Abstract

KBrO₃-mediated renal injury and hyperproliferative response in Wistar rats. In this communication, we report the efficacy of Nymphaea alba on KBrO₃ (125 mg/kg body weight, intraperitoneally) caused reduction in renal glutathione content, renal antioxidant enzymes and phase-II metabolising enzymes with enhancement in xanthine oxidase, lipid peroxidation, γ-glutamyl transpeptidase and hydrogen peroxide (H₂O₂). It also induced blood urea nitrogen, serum creatinine and tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and DNA synthesis. Treatment of rats with Nymphaea alba (100 and 200 mg/kg body weight) one hour before KBrO₃ (125 mg/kg body weight, i.p.) resulted in significant decreases in xanthine oxidase lipid peroxidation, γ-glutamyl transpeptidase, H₂O₂ generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant levels These results show that Nymphaea alba acts as chemopreventive agent against KBrO₃-mediated renal injury and hyperproliferative response.

Keywords: :

• Chemoprevention
• Nymphaea alba
• oxidative stress
• potassium bromate
• hyperproliferative response