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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 19, 2004 - Issue 5
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Research Article

Isatin-derived Antibacterial and Antifungal Compounds and their Transition Metal Complexes

Zahid H. Chohan Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan
,
Humayun Pervez Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan
,
A. Rauf Department of Chemistry, Islamia University, Bahawalpur, Pakistan
,
Khalid M. Khan HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
&
Claudiu T. Supuran Dipartmento di Chimica, Laboratorio di Chimica Bioinorganica, University of Florence, Via della Lastruccia 3 Rm. 188 Polo Scientifico, Sesto Fiorentino, 50019, Firenze, ItalyCorrespondence[email protected]
Pages 417-423 | Received 06 Oct 2003, Accepted 15 Mar 2004, Published online: 03 Oct 2008
 
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Abstract

A series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, IR, NMR and electronic spectral data. These compounds have been screened for antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the synthesized compounds have shown good affinity as antibacterial and/or antifungal agents which increased in most of the cases on complexation with the metal ions.

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