Spectral analysis and in vitro cytotoxicity profiles of novel organotin(IV) esters of 2-maleimidopropanoic acid

Abstract

Six novel triorganotin(IV) 2-maleimidopropanoato complexes: R₃SnOCOCH₃(CH)(COCH)₂, (R: Me(1), Et(2), n-Pr(3), n-Bu(4), Ph(5), Bz(6) have been synthesized. Their solid-state configuration has been determined by FT IR and ^119mSn Mössbauer spectroscopy. The tin(IV) atom is five-coordinated in all the complexes with 2-maleimidopropanoic acid behaving as a monoanionic bidentate ligand coordinating the tin(IV) atom through a chelating or bridging carboxylate group. The solution-state configuration has been elucidated by means of ¹H-, ¹³C- and ¹¹⁹Sn-NMR spectroscopy which assigned a tetrahedron. Elemental analysis and FAB MS data also supported a 1:1 metal to ligand stoichiometry. The title complexes have been screened in vitro for anti-tumour, anti-fungal, anti-leishmanial and urease inhibition activities and displayed promising results.

Keywords::

• Triorganotin(IV)
• 2-maleimidopropanoic acid
• urease inhibition
• anti-tumour
• anti-leishmanial
• anti-fungal

Acknowledgements

This work was carried out with the financial support of Gomal University, D. I. Khan, Pakistan, (Research Project No. 717-29/DF/GU).