Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives

Abstract

Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10^{− 3} M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C.albicans whereas the others had weak effects.

Keywords::

• Thiosemicarbazides
• thiadiazolylmethylbenzimidazoles
• triazolylmethylbenzimidazoles
• antimicrobial activity
• antioxidant activity
• lipid peroxidation