Synthesis, spectroscopic and biological aspects of iron(II) complexes

Abstract

Five novel coordinated complexes of iron(II) with ciprofloxacin and neutral bidentate ligands have been prepared and characterized using elemental analyses, magnetic measurements, IR spectra, UV-VIS spectral, thermogravimetric analyses, ¹H-NMR and ¹³C-NMR. The antimicrobial activity of the individual ligands, metal salt and metal complexes with respect to Bacillus subtilis, Escherichia coli, Bacillus cereus, Staphylococcus aureus, Salmonella typhi, Serratia marcescens, Aspergillus niger, Aspergillus flavus and Lasiodiplodia theobromae were evaluated by the agar-plate technique in comparison to reference standard drugs (ofloxacin, levofloxacin and fluconozole). Binding of the complexes to DNA was studied and is discussed.

Keywords::

• Ciprofloxacin
• quinolone-iron(II) complexes
• Schiff bases
• antimicrobial activity

Acknowledgements

We thank Prof. J. S. Parmar, Head, Department of Chemistry, and Prof. D. Madammvar, Head, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India for providing the laboratory facilities.