Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

Y. Laras Laboratoire de Chimie Biomoléculaire, IBDM-UMR-6216-CNRS, Faculté des Sciences Luminy, Université de la Méditerranée, Marseille cedex 9, France,

N. Pietrancosta Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette, France, and

T. Tomita Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan

T. Iwatsubo Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan

J. L. Kraus Laboratoire de Chimie Biomoléculaire, IBDM-UMR-6216-CNRS, Faculté des Sciences Luminy, Université de la Méditerranée, Marseille cedex 9, France,Correspondence[email protected]

Abstract

Synthesis and biological evaluation of an spiro[benzoxazepine-piperidine] class of Aβ-peptide production inhibitors for treatment of Alzheimer's disease are described.

Keywords::

Acknowledgements

We are grateful to Professor K. Dudley (Université de la Méditerranée, IBDML) for the preparation of the manuscript.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

Information for

Open access

Opportunities

Help and information

Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

Abstract

Acknowledgements

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature