Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents

Abstract

In an effort to establish new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of compounds (5a-j) and (7a-j) which were evaluated against two Gram positive (S. aureus, B. subtilis), two Gram negative (S. typhosa, E. coli) strains and a yeast-like fungi (C. albicans) using the micro-dilution procedure. Among the synthesized compounds 2-(cyclohexyl amino)-4-(3,4-dimethoxy phenyl ethyl thioureido)-6-(2-chloro phenyl ureido) s-triazine (7e) and 2-(cyclohexyl amino)-4-(3,4-dimethoxy phenyl ethyl thioureido)-6-(4-chloro phenyl ureido) s-triazine (7g) proved to be effective with MIC (0.019 mg ML⁻¹) against S. typhosa & E. coli respectively.

Keywords::

• s-triazine
• thiourea
• antibacterial
• antifungal

Acknowledgement

The authors are thankful to the Dr. Prof K. R. Desai, Head of the chemistry and Bioscience Department of Veer Narmad South Gujarat University, Surat. The authors also express their sincere thanks to the SAIF, Punjab University, Chandigarh for spectral analysis.

Declaration of interest: The authors report no conflicts of interest.