Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties

Abstract

The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.

Graphical Abstract

Keywords:

• Curcumin
• piperine
• cyclodextrin
• hyaluronidase
• acetylcholinesterase

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The scientific work was performed within the project “Uniwersalna platforma modułowa do przeprowadzania badań uwalniania symulujących warunki fizjologiczne dla doustnych postaci leku” supported by The National Centre for Research and Development in the program EUROSTARS-2.