Antibody persistence following meningococcal ACWY conjugate vaccine licensed in the European Union by age group and vaccine

ABSTRACT

Introduction

Meningococcal disease caused by Neisseria meningitidis is a major cause of meningitis and septicemia with high rates of morbidity and mortality worldwide. MenACWY-TT and MenACWY-CRM₁₉₇ are meningococcal conjugate vaccines approved for use in children and adults in the UK. The aim of this review was to evaluate and compare antibody responses and persistence in different age groups after MenACWY-TT and MenACWY-CRM₁₉₇.

Areas covered

Randomized trials showed that MenACWY-TT is immunogenic at all ages. MenACWY-CRM₁₉₇ is immunogenic for infants and adults, but there is a lack of data for children aged 1 to 2 years. Studies on MenACWY-TT indicated that serum bactericidal antibody (SBA) utilizing baby rabbit complement (rSBA) titers were significantly higher and more stable than SBA using human complement (hSBA) titers, compared with hSBA titers, which were lower and declined more rapidly by 1 year following post-primary MenACWY-TT and MenACWY-CRM₁₉₇ vaccination, especially for MenA.

Expert opinion

MenACWY-TT and MenACWY-CRM₁₉₇ are both well tolerated and induce similar antibody persistence and immunogenicity against all four serogroups for individuals more than one year old. rSBA assay is a more robust assay than the hSBA assay when vaccinating with MenACWY-TT, while rSBA and hSBA assays had similar antibody persistence when vaccinating with MenACWY-CRM₁₉₇.

KEYWORDS:

• MenACWY-TT
• MenACWY-CRM₁₉₇
• meningococcal
• antibody persistence
• conjugate vaccines

Declaration of interest

RB performs contract research on behalf of Public Health England for GSK, Pfizer and Sanofi Pasteur. WL and PDA declare no conflicts of interest.