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Original Research

Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler

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Pages 223-226 | Accepted 05 Jan 2005, Published online: 12 Jul 2009
 

Abstract

BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers.

OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection.

METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3‐mm punch tissue biopsy was taken at 1 and 6 months post‐injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated.

RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time.

CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.

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