Treatment of refractory acne using selective sebaceous gland electro-thermolysis combined with non-thermal plasma

ABSTRACT

Acne is one of the most common skin diseases whose disfiguring results may cause psychological problems. Despite of the various choices in the treatment of acne, new therapy with fewer complications and lower relapse rate is still in need. In this study, we aim to evaluate the clinical efficacy of a new therapy using selective sebaceous gland electro-thermolysis and non-thermal plasma (NTP) in refractory acne patients. Treatments were given at a monthly interval for three times. The last visit was set at 3 months after the third treatment. Thirty-six moderate to very severe acne patients were enrolled. All the patients got more than 50% clearance after the third treatment. The excellent response rate was 44% at 1 month after the third treatment and 50% at 3 months after the third treatment. Porphyrin and erythema values were significantly reduced after the third treatment. No irreversible complication was reported. Selective sebaceous gland electro-thermolysis combined with NTP can be a safe and effective new option in the treatment of acne.

KEYWORDS:

• Acne
• lasers
• therapy

Disclosure statement

Peninsula Medical Co. Ltd provided the microneedles.

Abbreviations

Non-thermal plasma (NTP), Cutibacterium acnes (C. acnes), photodynamic therapy (PDT), reactive oxygen species (ROS), ultraviolet (UV), microneedle radiofrequency (MRF), radiofrequency (RF), Investigator’s Global Assessment (IGA)

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.